Cobamide-mediated enzymatic reductive dehalogenation via long-range electron transfer
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چکیده
منابع مشابه
Cobamide-mediated enzymatic reductive dehalogenation via long-range electron transfer
The capacity of metal-containing porphyrinoids to mediate reductive dehalogenation is implemented in cobamide-containing reductive dehalogenases (RDases), which serve as terminal reductases in organohalide-respiring microbes. RDases allow for the exploitation of halogenated compounds as electron acceptors. Their reaction mechanism is under debate. Here we report on substrate-enzyme interactions...
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The discovery and characterization of several forms of cobamide coenzymes have been the subject of a series of reports from this laboratory within the past several years (1, 2). Cobamide coenzymes contain an adenosyl moiety (3) in which carbon atom 5’ is linked to reduced cobalt (4) in the corrin ring. Preliminary reports by Pawelkiewicz, Bartosinski, and Walerych (5) and Bernhauer et al. (6) i...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2017
ISSN: 2041-1723
DOI: 10.1038/ncomms15858